数一数中国一流大学的医学院和生科院院所长（1）

1.中国医学科学院、协和医科大学校长刘德培
中国科学院院士院士，
中国医学科学院基础所生化博士，
加州大学旧金山分校博士后
代表文章:

(1). U MJ, Lv X, Hao DL, Zhao GW, Wu XS, Wu F, Liu DP, Liang CC. MafK/NF-E2
p18 is required for beta-globin genes activation by mediating the proximity
of LCR and active beta-globin genes in MEL cell line.Int J Biochem Cell Biol
. 2008;40(8):1481-93.

(2). Zhou GL, Xin L, Song W, Di LJ, Liu G, Wu XS, Liu DP, Liang CC. Active
chromatin hub of the mouse alpha-globin locus forms in a transcription
factory of clustered housekeeping genes.
Mol Cell Biol. 2006 Jul;26(13):5096-105.

(3). Li HL, Wang AB, Zhang R, Wei YS, Chen HZ, She ZG, Huang Y, Liu DP,
Liang CC. A20 inhibits oxidized low-density lipoprotein-induced apoptosis
through negative Fas/Fas ligand-dependent activation of caspase-8 and
mitochondrial pathways in murine RAW264.7 macrophages.
J Cell Physiol. 2006 Aug;208(2):307-18.

(4). Liu DP.[Research of whole genome regulatory network in postgenomic era]
Zhonghua Yi Xue Za Zhi (中华医学杂志）. 2005 Sep 21;85(36):2526.

(5). Shen W, Huang Y, Tang Y, Liu DP, Liang CC. A general method to modify
BACs to generate large recombinant DNA fragments.Mol Biotechnol. 2005 Nov;31
(3):181-6.

(6). Lv X, Shi HZ, Liu DP, Hao DL, Zhang S, Xin L, Li XG, Xu HM, Liang CC.
High fidelity screening of regulatory sequences in apolipoprotein(a)-
plasminogen cluster.
Int J Biochem Cell Biol. 2005 Sep;37(9):1846-57.

(7). Wu XS, Xin L, Yin WX, Shang XY, Lu L, Watt RM, Cheah KS, Huang JD, Liu
DP, Liang CC.
Increased efficiency of oligonucleotide-mediated gene repair through slowing
replication fork progression.Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):
2508-13

(8). Liu DP, Schmidt C, Billings T, Davisson MT. Quantitative PCR genotyping
assay for the Ts65Dn mouse model of Down syndrome.Biotechniques. 2003 Dec;
35(6):1170-4。

(9). Feng DX, Liu DP, Huang Y, Wu L, Li TC, Wu M, Tang XB, Liang CC.The
expression of human alpha -like globin genes in transgenic mice mediated by
bacterial artificial chromosome.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26)
:15073-7

2. 北京大学生命科学院院长饶毅
加州大学旧金山分校神经生物学博士
哈佛大学博士后
美国西北大学神经科学研究所副所长，正教授
北京生命科学研究所副所长
代表文章:

(1). Li X, Gao X, Liu G, Xiong W, Wu J, Rao Y. Netrin signal transduction
and the guanine nucleotide exchange factor DOCK180 in attractive signaling.
Nat Neurosci. 2008 Jan;11(1):28-35

(2). Cafferty P, Yu L, Long H, Rao Y. Semaphorin-1a functions as a guidance
receptor in the Drosophila visual system.J Neurosci. 2006 Apr 12;26(15):3999
-4003.

(3). Jiang H, Rao Y. Axon formation: fate versus growth.Nat Neurosci. 2005
May;8(5):544-6.

(4). Jiang H, Guo W, Liang X, Rao Y. Both the establishment and the
maintenance of neuronal polarity require active mechanisms: critical roles
of GSK-3beta and its upstream regulators.Cell. 2005 Jan 14;120(1):123-35

(5). Ward ME, Wu JY, Rao Y. Visualization of spatially and temporally
regulated N-WASP activity during cytoskeletal reorganization in living cells
.Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):970-4

(6). Ruan W, Long H, Vuong DH, Rao Y. Bifocal is a downstream target of the
Ste20-like serine/threonine kinase misshapen in regulating photoreceptor
growth cone targeting in Drosophila.Neuron. 2002 Dec 5;36(5):831-42.

(7). Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-
Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y. Signal transduction in neuronal
migration: roles of GTPase activating proteins and the small GTPase Cdc42 in
the Slit-Robo pathway.Cell. 2001

(8). Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y. Directional
guidance of neuronal migration in the olfactory system by the protein Slit.
Nature. 1999 Jul 22;400(6742):331-6.

3. 北京生命科学研究所王晓东所长
美国科学院院士
美国休斯医学研究所研究员
美国德州大学西南医学中心教授

代表文章:

(1). Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander,
Xiaodong Wang, Patrick G. Harran, \"A Small Molecule Smac Mimic Potentiates
TRAIL- and TNF-Mediated Cell Death\" Science, 305(5689):1471-1474, September
2004;

(2). Xuejun Jiang, Hyun-Eui Kim, Hongjun Shu, Yingmin Zhao, Haichao Zhang,
James Kofron, Jennifer Donnelly, Dave Burns, Shi-chung Ng, Saul Rosenberg,
and Xiaodong Wang, \"Distinctive roles of PHAP proteins and prothymosin-
alpha in a death Regulatory Pathway.\" Science, 299:214-5, January 2003;

(3). Chunying Du, Min Fang, Yucheng Li, Lily Li, and Xiaodong Wang, \"Smac,
a mitochondrial protein that promotes cytochrome c-dependent caspase
activation by eliminating IAP inhibition.\" Cell, 102:33-42, 2000;

(4). Xuesong Liu, Caryn Naekyung Kim, Jie Yang, Ronald Jemmerson, and
Xiaodong Wang, \"Induction of apoptotic program in cell-free extracts:
requirement for dATP and cytochrome c.\" Cell, 86:147-157, 1996;

(5). Xu Luo, Imawati Budihardjo, Hua Zou, Clive Slaughter, and Xiaodong Wang
, \"Bid, a Bcl-2 interacting protein, mediates cytochrome c release from
mitochondria in response to activation of cell surface death receptors.\"
Cell, 94:481-490, 1998;

(6). Lai Wang, Fenghe Du, and Xiaodong Wang, \"TNF-_ induces two distinct
caspase-8 activation pathways\" Cell, 133:693-703, May 2008.

4. 北京大学基础医学院院长新任院长尹玉新
中国协和医科大学医学博士
美国北卡大学教堂山分校遗传与分子生物学博士
美国索克（Salk)研究所博士后
哥伦比亚大学放射肿瘤学副教授
代表文章:

(1). Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP and Yin Y.
Essential
role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-70,
2007.

(2). Wang J, Yin DP, Liu YX, Baer R and Yin Y. Dual specificity phosphatase
1/
CL100 is a direct transcriptional target of E2F-1 in the apoptotic response
to oxidative stress. Cancer Res 67:6737-44, 2007.

(3). Wang J, Liu YX, Hande MP, Wong AC, Jin YJ and Yin Y. TAp73 is a
downstream
target of p53 in controlling the cellular defense against stress. J Biol
Chem 282:29152-62, 2007.

(4). Wu J, Jin YJ, Calaf GM, Huang WL and Yin Y. PAC1 is a direct
transcription
target of E2F-1 in apoptotic signaling. Oncogene 26:6526-35, 2007.

(5). Yin Y, Zhu A, Jin YJ, Liu YX, Zhang X, Hopkins KM and Lieberman HB.
Human
RAD9 checkpoint control/proapoptotic protein can activate transcription of
p21. Proc Natl Acad Sci U S A 101:8864-9, 2004.

(6). Yin Y, Liu YX, Jin YJ, Hall EJ and Barrett JC. PAC1 phosphatase is a
transcription target of p53 in signalling apoptosis and growth suppression.
Nature 422:527-31, 2003.

(7). Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack
DH and
Levine AJ. Analysis of p53-regulated gene expression patterns using
oligonucleotide arrays. Genes Dev 14:981-93, 2000.

(8). Yin Y, Terauchi Y, Solomon GG, Aizawa S, Rangarajan PN, Yazaki Y,
Kadowaki T
and Barrett JC. Involvement of p85 in p53-dependent apoptotic response to
oxidative stress. Nature 391:707-10, 1998.

(9). Yin Y, Tainsky MA, Bischoff FZ, Strong LC and Wahl GM. Wild-type p53
restores cell cycle control and inhibits gene amplification in cells with
mutant p53 alleles. Cell 70:937-48, 1992.


5. 复旦大学生命科学学院长马红
麻省理工学院生物学博士
加州理工学院博士后
宾西法尼亚州立大学生物系杰出教授
代表文章:

(1).Quan, L.*, Xiao, R.*, Li, W., Oh, S.-A., Ambrose, J.C., Cyr, R., Twell,
D., Ma, H. 2008. Functionally divergence of the duplicated Arabidopsis
AtKIN14a and AtKIN14b genes: critical roles in meiosis and gametophyte
development. Plant J. 53: 1013-1026. (Equal contribution)

(2).Hu, W., Ma, H. 2006. Characterization of a novel putative zinc-finger
gene MIF1: involvement in multiple hormonal regulation of Arabidopsis
development. Plant J. 45: 399-422. (cover)

(3). Zhang, W.*, Sun, Y.*, Timofejeva, L., Chen, C., Grossniklaus, U., Ma, H
. 2006. Control of Arabidopsis tapetum development by DYSFUNCTIONAL TAPETUM
1 (DYT1) encoding a putative bHLH transcription factor. (* Equal
contribution) Development , 133: 3085-3095.

(4). Li, W., Chen, C., Markmann-Mulisch, U., Timofejeva, L., Schmelzer, E.,
Ma, H .*, and Reiss, B.* 2004. The Arabidopsis RAD51 gene is dispensable for
vegetative growth but required for meiosis . Proc. Natl. Acad. Sci. USA.
101 : 10596-10601. (* Corresponding authors);

(5). Yang, X.-H., Makaroff, C.*, Ma, H .* 2003. The Arabidopsis MALE
MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male
meiosis. Plant Cell 15 : 1281-1295.

(6). Zhao, D.-Z., Wang, G.-F., Speal, B., Ma, H . 2002. The EXCESS
MICROSPOROCYTES1 gene encodes a putative leucine-rich repeat receptor
protein kinase that controls somatic and reproductive cell fates in the
Arabidopsis anther. Genes & Dev . 16 : 2021-2031.

(7). Ma, H ., dePamphilis, C. 2000. The ABCs of floral evolution. Cell 101 :
5-8.

(8). Ma, H. 1997. The on and off of floral regulatory genes. Cell 89: 821-
824.

(9). Mizukami, Y., Ma, H. 1992. Ectopic expression of the floral homeotic
gene AGAMOUS in transgenic Arabidopsis plants alters floral organ identity.
Cell 71: 119-131.

(10). Ma, H., Yanofsky, M.F., Meyerowitz, E.M. 1991. AGL1-AGL6, An
Arabidopsis gene family with similarity to floral homeotic and transcription
factor genes. Genes & Dev. 5: 484-495.

6. 中国科学院上海生命科学院院长裴刚
中国科学院院士、第三世界科学院院士
美国北卡大学教堂山分校生化博士
杜克大学医学院博士后

(1).Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E,
Zang L, Lu C, Zhang JZ, Pei G. Critical regulation of CD4+ T cell survival
and autoimmunity by beta-arrestin 1.Nat Immunol. 2007 Aug;8(8):817-24.

(2).Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei
G. Activation of beta2-adrenergic receptor stimulates gamma-secretase
activity and accelerates amyloid plaque formation.Nat Med. 2006 Dec;12(12):
1390-6.

(3). Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. Association of beta-
arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1
receptor signaling.Nat Immunol. 2006 Feb;7(2):139-47

(4). Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F,
Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L. A nuclear function of beta-
arrestin1 in GPCR signaling: regulation of histone acetylation and gene
transcription.Cell. 2005 Dec 2;123(5):833-47.

(5). Luan B, Zhang Z, Wu Y, Kang J, Pei G. Beta-arrestin2 functions as a
phosphorylation-regulated suppressor of UV-induced NF-kappaB activation.EMBO
J. 2005 Dec 21;24(24):4237-46.

(6). Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G. Identification of beta
-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB
pathways. Mol Cell. 2004 May 7;14(3):303-17.

(7). Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G. Beta-
arrestin 2 functions as a G-protein-coupled receptor-activated regulator of
oncoprotein Mdm2.J Biol Chem. 2003 Feb 21;278(8):6363-70.

7. 中国科学院广州生物医药与健康研究院院长陈凌
美国印第安那大学生化与分子生物博士
哈佛大学医学院Dana-Farber癌症研究所博士后
美国Lexicon Genetics Inc, 生物制药部主任

(1).Casimiro DR, Chen L, Fu TM, Evans RK, Caulfield MJ, Davies ME, Tang A,
Chen M, Huang L, Harris V, Freed DC, Wilson KA, Dubey S, Zhu DM, Nawrocki D,
Mach H, Troutman R, Isopi L, Williams D, Hurni W, Xu Z, Smith JG, Wang S,
Liu X, Guan L, Long R, Trigona W, Heidecker GJ, Perry HC, Persaud N, Toner
TJ, Su Q, Liang X, Youil R, Chastain M, Bett AJ, Volkin DB, Emini EA, Shiver
JW. Comparative immunogenicity in rhesus monkeys of DNA plasmid,
recombinant poxvirus and replication-defective adenoviral vectors expressing
a human immunodeficiency virus type 1 gag gene.J Virology.2003, 77:6305-
6313.

(2). Shiver JW, Fu TM, Chen L, Casimiro DR, Davies ME, Evans RK, Zhang ZQ,
Simon AJ, Trigona WL, Dubey SA, Huang L, Harris VA, Long RS, Liang X, Handt
L, Schleif WA, Zhu L, Freed DC, Persaud NV, Guan L, Punt KS, Tang A, Chen M,
Wilson KA, Collins KB, Heidecker GJ, Fernandez VR, Perry HC, Joyce JG,
Grimm KM, Cook JC, Keller PM, Kresock DS, Mach H, Troutman RD, Isopi LA,
Williams DM, Xu Z, Bohannon KE, Volkin DB, Montefiori DC, Miura A, Krivulka
GR, Lifton MA, Kuroda MJ, Schmitz JE, Letvin NL, Caulfield MJ, Bett AJ,
Youil R, Kaslow DC, Emini EA. Replication-incompetent adenoviral vaccine
vector elicits effective anti-immunodeficiency-virus immunity. Nature. 2002,
415:331-335.

(3). Chen L, Chen D, Block E, O\'Donnell M, Kufe DW, Clinton, SK.Eradication
of murine bladder carcinoma by intratumor injection of a bicistronic
adenoviral vector carrying cDNAs for Interleukin-12 heterodimer and its
inhibition by the IL-12 p40 subunit homodimer.Journal of Immunology, 1997,
159:351-359.

(4). Chen L, Yu L, Waxman DJ.Potentiation of cytochrome P450/
cyclophosphamide-based cancer gene therapy by transfer of the P450 reductase
gene. Cancer Research, 1997, 57:4830-4837.

(5). Chen L, Pulsipher M, Chen D, Elias A, Sieff C, Fine HA, Kufe DW.
Adenovirus mediated transgene expression for detection and elimination of
contaminating carcinoma cells in hematopoietic stem cell sources. Journal of
Clinical Investigation, 1996, 98:2539-2548
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