What can you do with cancer? It's under-treatment; it's now over-treatment - a scary journey upon talking about cancer. If you change the concept, not near-death, or dead now disease; let say, it's a chronicle, a aging disease - don't you feel better? As you have more time to deal with, you can afford "Wait-and-see? Watch-and-wait?"
The hardest to treat, not a disease, but perception - change the perception, you may have a better idea. Your brain, your heart, gotta change!
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Curr Stem Cell Res Ther. 2017 Mar 6. doi:
10.2174/
Tissue elasticity bridges cancer stem cells to the tumor
microenvironment through microRNAs: Implications for a
"watch-and-wait" approach to cancer.
Kabeer MH1, Loudon WG1, Dethlefs BA1, Li Z2, Zhong JF2, Luo JJ3, Vu LT1, Li SC4.
Author information
1Neuro-Oncology and Stem Cell Research Laboratory, Center for
Neuroscience Research, CHOC Children`s Hospital Research Institute,
1201 West La Veta Ave., Orange, CA 92868. United States.2Division of
Periodontology, Diagnostic Sciences & Dental Hygiene and Biomedical
Sciences, Ostrow School of Dentistry, University of Southern
California, Los Angeles, CA 90089. United States.3AB Sciex, Inc.,
Brea, CA 90631. United States.4University of California Irvine School
of Medicine - CHOC Children`s Hospital- Orange, CA. United States.
Abstract
Targeting the tumor microenvironment (TME) through which cancer stem
cells (CSCs) crosstalk for cancer initiation and progression, may open
up new treatments different from those centered on the original
hallmarks of cancer genetics, which are specific for (CSCs). Cancer is
dynamic, heterogeneous, evolving with the TME and can be influenced by
tissue-specific elasticity. One of the mediators and modulators of the
crosstalk between CSCs and mechanical forces is miRNA, which can be
developmentally regulated, tissue- and cell-specific. Here, based on
our previous data, we provide a framework through which such gene
expression changes in response to external mechanical forces can be
understood during cancer progression. Recognizing the ways mechanical
forces regulate and affect intracellular signals has applications in
cancer stem cell biology. Such TME-targeted pathways shed new light on
attacking cancer stem cells with fewer side effects than traditional
gene-based treatments for cancer, requiring a "watch-and-wait"
approach. We attempt to address both normal brain microenvironment and
tumor microenvironment as both works together, intertwining in
pathology and physiology - a balance that needs to be maintaining for
the "watch-and-wait" approach to cancer.
Copyright© Bentham Science Publishers; For any queries, please email
at epub@benthamscience.org.
KEYWORDS:
Tissue elasticity; cancer stem cells; gene expression; miRNAs
PMID: 28270089 DOI: 10.2174/
https://www.ncbi.nlm.nih.gov/
