https://www.nature.com/articles/s41598-022-20202-x
Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp.
喜欢这篇文章，从方法到语气。
生物圈，很多文章充满着虚妄的傲慢。好像新冠已经是他们的囊中物了，
这文章上来首先就是承认，C19重症在科学上依然是个迷。然后证明莱姆病抗体与c19重症的强关联，然后承认里因果性原理的理解还早。
语气上显示了传统科学家的严谨。
Predictors for the risk of severe COVID-19 are crucial for patient care and control of the disease. Other infectious diseases as potential comorbidities in SARS-CoV-2 infection are still poorly understood. Here we identify association between the course of COVID-19 and Lyme disease (borreliosis), caused by Borrelia burgdorferi transmitted to humans by ticks. Exposure to Borrelia was identified by multi-antigenic (19 antigens) serological testing of patients: severe COVID-19 (hospitalized), asymptomatic to mild COVID-19 (home treated or not aware of being infected), and not infected with SARS-CoV-2. Increased levels of Borrelia-specific IgGs strongly correlated with COVID-19 severity and risk of hospitalization. This suggests that a history of tick bites and related infections may contribute to the risks in COVID-19. Though mechanisms of this link is not clear yet, screening for antibodies targeting Borrelia may help accurately assess the odds of hospitalization for SARS-CoV-2 infected patients, supporting efforts for efficient control of COVID-19.
严重 COVID-19 风险的预测因子对于患者护理和疾病控制至关重要。其他传染病作为 SARS-CoV-2 感染的潜在合并症仍然知之甚少。在这里，我们确定了 COVID-19 病程与莱姆病（疏螺旋体病）之间的关联，莱姆病是由伯氏疏螺旋体通过蜱传播给人类引起的。通过对患者的多抗原（19 种抗原）血清学检测确定是否接触过疏螺旋体：重症 COVID-19（住院）、无症状至轻度 COVID-19（家庭治疗或不知道被感染）和未感染 SARS-CoV -2。疏螺旋体特异性 IgG 水平升高与 COVID-19 的严重程度和住院风险密切相关。这表明蜱叮咬和相关感染的病史可能会增加 COVID-19 的风险。尽管这种联系的机制尚不清楚，但筛查针对疏螺旋体的抗体可能有助于准确评估 SARS-CoV-2 感染患者的住院几率，从而支持有效控制 COVID-19 的努力。
