東方明珠中國風:How many people die of the flu each year, on average?According to data collected by the CDC from 2010 to 2020, the agency estimates that the flu has caused 12,000–52,000 deaths annually. During that time, the flu also caused 9 million–41 million illnesses, and 140,000–710,000 hospitalizations. Globally, the World Health Organization (WHO) estimates that the flu kills 290,000 to 650,000 people per year.