Although the ideal dose of melatonin has not yet been standardized, some clinical studies, in addition to our own results, have shown that daily oral doses of 20–40 mg (distributed evenly throughout the day with greater concentrations in the evening) [149–151], up to a maximum of 1000 mg of Melatonin administered slowly and intravenously during the day, are perfectly well tolerated, with useful and beneficial effects for the patients [152,153]. In over 42 years of experience in the clinical use of MLT by Luigi Di Bella, Giuseppe Di Bella and others, the dose has been gradually increased, without toxicity or significant side effects, except for temporary drowsiness reported by some patients, generally at the start of the treatment, and very rarely making it necessary to reduce the dose.
