Grubbs catalyst

  First-generation Grubbs catalyst

It is synthesized from RuCl2(PPh3)3, phenyldiazomethane, and tricyclohexylphosphine in a one-pot synthesis.

Preparation of the first-generation Grubbs catalyst

Second-generation catalyst

Synthesis of the second–generation Grubbs catalyst

The second-generation catalyst has the same uses in organic synthesis as the first generation catalyst, but generally with higher activity. This catalyst is stable toward moisture and air, thus is easier to handle in the lab.

Hoveyda–Grubbs catalysts

First-generation Hoveyda–Grubbs catalyst

Hoveyda-katalysator.svg

Second-generation Hoveyda–Grubbs catalyst

Preparation of the Hoveyda–Grubbs catalyst from the second–generation Grubbs catalyst

Preparation of the Hoveyda–Grubbs catalyst from the first-generation version

The Hoveyda–Grubbs catalysts, while more expensive and slower to initiate than the Grubbs catalyst from which they are derived, are popular because of their improved stabilit.

 

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