Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause. The loss of estrogens with aging contributes to diminished dermal health, whereas estrogen hormone therapy [eg, oral conjugated equine estrogens (CEE)] restores skin health。
https://pubmed.ncbi.nlm.nih.gov/29436770/#:~:text=Estrogen%20levels%20peak%20in%20the,dramatically%20decrease%20further%20after%20menopause.?
