Pomegranate contains plant estrogens, which have estrogenic activities. Some breast cancer patients can not take it if they underline anti-estrogen therapy.
ii
Another study demonstrated that pomegranate juice inhibited breast cancer cell growth, but also increased cell adhesion and reduced cell migration and inhibited chemotaxis. Pomegranate juice also inhibited genes important for inducing the epithelial-to-mesenchymal transition.Dec 15, 2017
Studies have shown the beneficial effects of pomegranates in breast cancer [73]. Kim et al. [74] reported that polyphenols from fermented PJ, pericarp, and PSO inhibited aromatase, which converts androgen to estrogen and plays an important role in breast carcinogenesis.Jan 24, 2017
Pomegranate contains plant estrogens, which have estrogenic activities. Because of this some researchers have suggested that pomegranate is clinically helpful for menopausal women to improve depressive states and bone loss.
Cancer. Pomegranate is high in antioxidants and other nutrients, so some people think that drinking pomegranate juice regularly may help prevent cancer. In test tubes, pomegranate extracts made from juice, rind, and oil slow down the reproduction of cancer cells and may hasten their death.
Its anti-inflammatory properties may help reduce the risk of developing cancer. In preclinical and animal models, pomegranate has been shown to reduce existing cancer cell growth, induce cell death, prevent blood vessel growth associated with tumors, and inhibit the spread of cancer cells in the body.
In a 2016 study published in the journal Antioxidants, researchers found that blackberries and blueberries, in particular, may destroy breast tumors and cancer cells. Berries go great with cereal, Greek yogurt, and oatmeal. They can also get added to fruit salads.Oct 11, 2021
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Mayo Clinic https://www.mayoclinic.org/drugs-supplements/anastrozole-oral-route/side-effects/drg-20061868?p=1
Drugs and Supplements
Anastrozole (Oral Route)
Description and Brand Names
Drug information provided by: IBM Micromedex
US Brand Name
Arimidex
Descriptions
Anastrozole is used to treat early hormone receptor-positive breast cancer. It is also used for first-line treatment of hormone receptor-positive or hormone receptor-unknown advanced or metastatic (cancer that has spread) breast cancer. Anastrozole is also used to treat advanced breast cancer that has grown or spread after tamoxifen treatment. This medicine is used only in women who have already stopped menstruating (postmenopausal).
Many breast cancer tumors grow in response to estrogen. This medicine interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
Tablet
Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anastrozole in children. However, efficacy has not been established to treat teenage boys with pubertal gynecomastia and to treat precocious puberty in teenage girls with McCune-Albright Syndrome.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anastrozole in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Bone problems (eg, osteoporosis) or
Hypercholesterolemia (high cholesterol or fat in the blood) or
Ischemic heart disease (eg, heart attack, angina), history of, or
Liver disease—Use with caution. May make these conditions worse.
Premenopausal women (still having menstrual cycles)—Should not be used in these patients.
Proper Use
Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.
This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.
You may take this medicine with or without food.
Anastrozole sometimes causes nausea, vomiting, or diarrhea. However, it is very important that you continue to use the medicine, even if you begin to feel ill. Ask your doctor for ways to prevent these effects or make them less severe.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets):
For breast cancer:
Adults—1 milligram (mg) once a day.
Children—Use and dose must be determined by your doctor.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
It is unlikely that a postmenopausal woman may become pregnant. But, you should know that using this medicine while you are pregnant could harm your unborn baby. Use an effective form of birth control during treatment with this medicine and for at least 3 weeks after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.
Do not use this medicine together with tamoxifen (Nolvadex?, Soltamox?).
This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
Check with your doctor right away if you start having chest pains or difficulty with breathing. This medicine may increase the chance of heart problems, including heart attack, in women who have a history of ischemic heart disease.
This medicine may decrease bone mineral density when used for a long time. A low bone mineral density can cause weak bones or osteoporosis. If you have any questions about this, talk to your doctor.
This medicine may increase your cholesterol or fat in the blood. If this happens, your doctor may give you medicine to lower the cholesterol and fat.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Blurred vision
bone pain
chest pain or discomfort
dizziness
headache
nervousness
pounding in the ears
slow or fast heartbeat
swelling of the feet or lower legs
Less common
Arm, back, or jaw pain
chest tightness or heaviness
chills
cough
cough producing mucus
difficult or painful urination
difficulty breathing
dizziness, severe
fever
headache, continuing
hoarseness
increased blood pressure
lower back or side pain
nausea
pain, tenderness, bluish color, or swelling of the foot or leg
sore throat
sweating
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
vaginal bleeding (unexpected and heavy)
Incidence not known
Blistering, peeling, or loosening of the skin
confusion
constipation
dark urine
depression
diarrhea
difficulty swallowing
dry mouth
general tiredness and weakness
hives or welts, itching, skin rash
incoherent speech
increased urination
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
light-colored stools
loss of appetite
metallic taste
muscle weakness
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or on the lips
stomach pain
thirst
upper right abdominal pain
vomiting
weight loss
yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Back pain
belching
body aches or pain
congestion
decrease in height
feeling of warmth
flushing or redness of the skin, especially on the face and neck
heartburn
increased appetite
indigestion
lack or loss of strength
mood or mental changes
pain in the back, ribs, arms, or legs
pain, general
pelvic pain
runny nose
stomach discomfort or upset
tender, swollen glands in the neck
trouble in swallowing
voice changes
Less common
Anxiety
breast pain
dryness of the vagina
general feeling of discomfort or illness
joint stiffness
loss of hair
numbness or tingling of the hands or feet
shivering
sleepiness
trouble sleeping
weight gain
Incidence not known
Difficulty in moving
muscle cramps or stiffness
swollen joints
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Portions of this document last updated: Nov. 01, 2022
Original article: https://www.mayoclinic.org/drugs-supplements/anastrozole-oral-route/side-effects/drg-20061868
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TJKCB 发表评论于
Ellagic acid found in pomegranates inhibits aromatase, an enzyme that converts androgen to estrogen. Aromatase plays a key role in breast carcinogenesis; therefore, the growth of breast cancer is inhibited.Jan 6, 2010
Natural compounds in pomegranates may prevent growth of ...
Does pomegranate lower estrogen?
They found that extracts of the seeds, which is what pomegranate juice really is, reduced the activity of 17-beta-estradiol, the estrogen of concern in breast cancer, by some 50%. And breast cancer cells which experienced this reduction in estrogen stimulation died with much greater frequency than normal cells.Mar 20, 2017
Pomegranate Frenzy | Office for Science and Society
==
Anastrozole
Medication
Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth. Wikipedia
Molar mass: 293.366 g/mol
Formula: C17H19N5
CAS ID: 120511-73-1
ChEMBL Id: 1399
ChemSpider ID: 2102
IUPHAR ID: 5137
Other names: Anastrazole; anastrozol; ICI-D1033; ZD-1033
Treatment duration
People being treated for primary breast cancer will usually take anastrozole for five to ten years. Some people start taking anastrozole after a number of years of taking another hormone therapy drug called tamoxifen.
Anastrozole (Arimidex) - Breast Cancer Nowhttps://breastcancernow.org ? hormone-therapy ? anastroz...
Search for: anastrozole length of treatment
Chemotherapy
Is anastrozole (Arimidex) a type of chemotherapy? Anastrozole (Arimidex) is considered a hormone therapy rather than a traditional chemotherapy medication. Chemotherapy is used to target and kill cancer cells, whereas anastrozole (Arimidex) is used to lower estrogen in the body.
