Department of Cell Biology
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115
Junying Yuan received her Ph.D. in Neuroscience from Harvard University in 1989 and her undergraduate degree from Fudan University, Shanghai, China, in 1982. Dr. Yuan carried out her Ph.D thesis work at the Massachusetts Institute of Technology. She was first appointed as Assistant Professor at Harvard Medical School in 1992, when she became a Principal Investigator of the Cardiovascular Research Center at Massachusetts General Hospital. She joined the Department of Cell Biology in 1996 and was appointed a Professor of Cell Biology at Harvard Medical School in 2000.
~~
Junying Yuan
| Junying Yuan | |
|---|---|
| Born | October 3, 1958 Shanghai |
| Nationality | American |
| Fields | Biology Cell death |
| Institutions | Harvard Medical School |
| Alma mater | Fudan University Harvard University Massachusetts Institute of Technology |
| Doctoral advisor | H. Robert Horvitz |
| Known for | Apoptosis research Necroptosis |
Junying Yuan (Chinese: 袁钧瑛; pinyin: Yuán Jūnyīng, born October 3, 1958) is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School,[1] best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.[2][3] More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.[4]
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Contents
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Education and early career[edit]
Junying Yuan was born in Shanghai, where she attended Fudan University following the revival of higher education after its suspension under the Cultural Revolution. She was among the first wave of students to attempt the newly revived National Higher Education Entrance Examination in 1977, coming in first of all students who attempted it in Shanghai.[5] She completed her Bachelors in Biochemistry in 1982, and was subsequently one of the first students admitted to doctoral study in the United States through the China-U.S. Biochemistry Examination and Application (CUSBEA) program, coming in second out of the 25,000 who attempted the CUSBEA in its first year.[6]
In the United States, she completed her PhD in Neuroscience(1989) at Harvard University under the supervision of MIT professor H. Robert Horvitz, where she endeavored to elucidate the molecular mechanisms behind programmed cell death in the nematode Caenorhabditis elegans. She identified the proteins ced-3 and ced-4 as drivers behind programmed cell death in C. elegans, and subsequently identified the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1.[2][3][7]
Career[edit]
Junying Yuan established an independent lab at Harvard-affiliated Massachusetts General Hospital in 1989, immediately upon completion of her PhD.[6] Her initial efforts were directed towards providing evidence for the functional role of caspases in mediating mammalian apoptosis.[8][9] Her independent work at this stage provided the first insights into molecular mechanisms in mammalian apoptosis, which contributed significantly to the Nobel Prize in Chemistry won by her PhD supervisor, Robert Horvitz.[10]
In 1996, Yuan moved her lab to the Department of Cell Biology at Harvard Medical School's Longwood campus, where she continued her investigation into cell death. Her work delved further into programmed cell death and revealed a wide cohort of proteins involved in the regulation and consequences of apoptosis. Some notable work includes her discovery that BID cleavage by caspase-8 mediates mitochondrial damage in apoptosis,[11] and her discovery of caspase-11's role in regulating caspase-1-driven inflammation.[12]
In 2005, Yuan's group discovered a non-apoptotic form of programmed necrotic cell death, which they termed "necroptosis".[4] Other groups first observed that the stimulation of Fas/TNFR family of death-domain receptors(DR) activated a canonical apoptotic pathway; however, in many cell types, not only did caspase inhibition fail to inhibit cell death, as would be expected of canonical apoptosis, but stimulated cells experienced a form of cell death that more closely resembled necrosis than apoptosis.[13] Yuan's group conducted a chemical screen that identified a small molecule capable of inhibiting DR-driven cell death, necrostatin-1, and demonstrated necroptosis' role in ischemic neuronal injury, thereby positing a potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1,[14] thus implicating it as a key player in necroptosis. Yuan went on to identify and characterize members of the signaling network responsible for regulating necroptosis,[15] and continues to elucidate the mechanisms of necroptosis while exploring its potential as a target of therapeutic intervention. Necrosis was previously considered to be a form of passive cell death, forced in response to stress. This belief had driven an aversion towards developing therapeutic applications targeting necrosis. In demonstrating a form of programmed necrosis, Yuan's work revealed new avenues of treatment for an ever-increasing cohort of diseases where necroptosis is implicated.[16]
Awards and Fellowships[edit]
- 1985-1989 Ryan Fellowship[17]
- 1994 Wilson S. Stone Memorial Award[18]
- 1996-1999 American Heart Established Investigator[19]
- 1999 SCBA Outstanding Young Investigator Award[19]
- 2002 Innovator Award for Breast Cancer Research[20]
- 2002 Merit Award, National Institute of Aging[19]
- 2003 BBS Mentoring Award, Harvard Medical School[19]
- 2005 National Institutes of Health Director's Pioneer Award
- 2006 International Cell Death Society Award[21]
- 2007 Fellow of the American Academy of Arts and Sciences[22]
- 2010 Fellow of the American Association for the Advancement of Science[23]
- 2013 Agilent Technologies Thought Leader Award[24]
References[edit]
- Jump up ^ "Yuan Named Hay Professor of Cell Biology". HMS News. Retrieved 13 May 2015.
- ^ Jump up to: a b Yuan, J. Y.; Horvitz, H. R. (1990). "The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death". Developmental Biology. 138 (1): 33–41. doi:10.1016/0012-1606(90)90174-h. PMID 2307287.
- ^ Jump up to: a b Yuan, J; Horvitz, H. R. (1992). "The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death". Development (Cambridge, England). 116 (2): 309–20. PMID 1286611.
- ^ Jump up to: a b Degterev, A; Huang, Z; Boyce, M; Li, Y; Jagtap, P; Mizushima, N; Cuny, G. D.; Mitchison, T. J.; Moskowitz, M. A.; Yuan, J (2005). "Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury". Nature Chemical Biology. 1 (2): 112–9. doi:10.1038/nchembio711. PMID 16408008.
- Jump up ^ "袁钧瑛". http://baike.baidu.com/ Baidu. Retrieved 16 May 2015. External link in
|work=(help) - ^ Jump up to: a b "Junying Yuan" (PDF). ASCB Profile. Retrieved 13 May 2015.
- Jump up ^ Yuan, J; Shaham, S; Ledoux, S; Ellis, H. M.; Horvitz, H. R. (1993). "The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme". Cell. 75 (4): 641–52. doi:10.1016/0092-8674(93)90485-9. PMID 8242740.
- Jump up ^ Miura, M; Zhu, H; Rotello, R; Hartwieg, E. A.; Yuan, J (1993). "Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. Elegans cell death gene ced-3". Cell. 75 (4): 653–60. doi:10.1016/0092-8674(93)90486-a. PMID 8242741.
- Jump up ^ Gagliardini, V; Fernandez, P. A.; Lee, R. K.; Drexler, H. C.; Rotello, R. J.; Fishman, M. C.; Yuan, J (1994). "Prevention of vertebrate neuronal death by the crmA gene". Science. 263 (5148): 826–8. doi:10.1126/science.8303301. PMID 8303301.
- Jump up ^ "H. Robert Horvitz - Nobel Lecture: Worms, Life and Death" (PDF). Nobel Prize. Retrieved 14 May 2015. External link in
|work=(help) - Jump up ^ Li, H; Zhu, H; Xu, C. J.; Yuan, J (1998). "Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis". Cell. 94 (4): 491–501. doi:10.1016/s0092-8674(00)81590-1. PMID 9727492.
- Jump up ^ Kang, S. J.; Wang, S; Hara, H; Peterson, E. P.; Namura, S; Amin-Hanjani, S; Huang, Z; Srinivasan, A; Tomaselli, K. J.; Thornberry, N. A.; Moskowitz, M. A.; Yuan, J (2000). "Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions". The Journal of Cell Biology. 149 (3): 613–22. doi:10.1083/jcb.149.3.613. PMC 2174843
. PMID 10791975. - Jump up ^ Vercammen, D; Brouckaert, G; Denecker, G; Van De Craen, M; Declercq, W; Fiers, W; Vandenabeele, P (1998). "Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways". The Journal of Experimental Medicine. 188 (5): 919–30. doi:10.1084/jem.188.5.919. PMC 2213397. PMID 9730893.
- Jump up ^ Degterev, A; Hitomi, J; Germscheid, M; Ch'En, I. L.; Korkina, O; Teng, X; Abbott, D; Cuny, G. D.; Yuan, C; Wagner, G; Hedrick, S. M.; Gerber, S. A.; Lugovskoy, A; Yuan, J (2008). "Identification of RIP1 kinase as a specific cellular target of necrostatins". Nature Chemical Biology. 4 (5): 313–21. doi:10.1038/nchembio.83. PMID 18408713.
- Jump up ^ Hitomi, J; Christofferson, D. E.; Ng, A; Yao, J; Degterev, A; Xavier, R. J.; Yuan, J (2008). "Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway". Cell. 135 (7): 1311–23. doi:10.1016/j.cell.2008.10.044. PMC 2621059. PMID 19109899.
- Jump up ^ Zhou, W; Yuan, J (2014). "Necroptosis in health and diseases". Seminars in Cell & Developmental Biology. 35: 14–23. doi:10.1016/j.semcdb.2014.07.013. PMID 25087983.
- Jump up ^ "Fellows of the Foundation". Albert J. Ryan Foundation. Retrieved 13 May 2015. External link in
|work=(help) - Jump up ^ "Wilson S. Stone Memorial Award Recipients" (PDF). Retrieved 13 May 2015.
- ^ Jump up to: a b c d "Junying Yuan - Curriculum Vitae".
- Jump up ^ "Innovator Award Recipients from the DOD Breast Cancer Research Program". U.S. Army Medical Research and Materiel Command. Retrieved 13 May 2015.
- Jump up ^ "Awardees". ICDS. Retrieved 13 May 2015. External link in
|work=(help) - Jump up ^ "Junying Yuan". American Academy of Arts and Sciences. Retrieved 14 May 2015.
- Jump up ^ "AAAS Members Elected as Fellows". American Association for the Advancement of Science. Retrieved 14 May 2015.
- Jump up ^ "Agilent Technologies Thought Leader Award Supports Dr. Junying Yuan, Chinese Academy of Sciences". Agilent Technologies. Retrieved 13 May 2015. External link in
|work=(help)
~~
袁均英 博士 在 哈佛 做过 正教授吗？
| 推荐到群组
袁均英博士1982年毕业于复旦大学生化系，1989年获哈佛大学神经科学博士，师从H.R.Harvitz教授。1992年聘为哈佛医学院神经科学助理教授，1997年晋升为副教授，2000年起任哈佛大学医学院终生教授，
我的理解是哈佛医学院没有 真正的 tenured 的。要靠基金养自己的。
哈佛医学院成为正教授非常 困难，而且 正教授的工资还是要靠基金的。
有没有知道的人愿意解释一下？
一些地方解释袁博士是哈佛的正教授，大概基于 中国的 认识，大概认为 终身教授 肯定 正教授。
看 中国 现在的网站 比 资本主义 还要 资本主义。
http://www.erasmusmc.nl/radiologie/?lang=en
荷兰最大医学影像系的网站
https://strahlentherapie.charite.de
德国一大型肿瘤放疗科的网站
xxx xxx 课题组 xxx lab Yan lab 这样这样的东东 反正我只有在中国的网站 照片上看到过。公有财产怎么可以写上成 跟个人的一样
我看到颜宁的实验室显微镜 上 写着 Yan lab.
我觉得是难以想象的
1 是公共财产 还是 私人财产？
2 为什么不用 本国文字？
----- 非正式的网站：
http://tieba.baidu.com/p/3143876438
袁均英太厉害了 哈佛医学院的正教授啊！！
通宵看号007: 哈佛大学的正教授啊，世界一流啊。
Interdisciplinary Research Center on Biology and Chemistry
-- 这个名字语法有没有问题？
http://blog.sciencenet.cn/blog-2649160-1019168.html
上一篇：中国的1980s是比较民主与浪漫主义的时代
2 孟佳 pota
发表评论 评论 (23 个评论)
- [23]李胜文
- the answer is "yes" - full professor with tenure. I worked in the Departmental Chair's lab, adjacent to Yuan's lab at Harvard. A major part of Horvitz's Nobel Prize work was done by Yuan, a giant in cell biology. She's member of American Academy of Arts and Science, Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School. Her English is superb! She chairs a lot of NIH Study Sections (grants) and symposiums nationwide. Harvard Cell Biology Department has 15 members of the National Academy of Sciences, USA - it's extremely competitive to get into the Faculty - it's cutting-throat to stay on the faculty, which tells a lot about Yuan work. Check the list for fellow Chinese faculty online (It used to have Rong Li, a girl professor).
junying yuan harvard
Junying Yuan
Junying Yuan is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School, best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis. Wikipedia
Born: October 3, 1958 (age 58), Shanghai, China
Field: Biology
Institution: Harvard Medical School
Alma maters: Fudan University, Harvard University, Massachusetts Institute of Technology
Academic advisor: H. Robert Horvitz
http://cellbio.med.harvard.edu/people/faculty/yuan
- [22]张义国
- tenured professor 翻译成 终生教授 及 Fellow 翻译成 院士: 这是错误!
A Tenured Professor (1990) is a satirical novel by Canadian/American economist and Professor Emeritus at Harvard, John Kenneth Galbraith, about a liberal university teacher who sets out to change American society by making money and then using it for the public good. Set at Harvard mainly during the Reagan administration, the plot and all the characters that appear in the story are entirely fictitious. 一个自由的大学老师开始赚钱美国社会的变革，然后用它为公益. 通俗翻译就是一个上了轨道的专业人。
The book chronicles the rise to fame of one Montgomery Marvin, a professor of economics who, as an academic teacher, keeps a low profile but who nevertheless is given tenure quite early in his career. While outwardly concerning himself with unspectacular research focusing on "Mathematical Paradigms in an Approach to Refrigerator Pricing" (which is also the title of his Ph.D. thesis), Marvin's extracurricular activities centre on becoming very rich in a very short time. For that purpose, Marvin has devised a new formula—a stock forecasting model by means of which he and his wife can cash in on people's euphoria, greed and, as they call it, dementia. Eventually, while everyone loses money in the wake of the "Black Monday" stock market crash of October 19, 1987, the Marvins gain an awful lot. (See also Michael Milken and leveraged buyout.)
They decide to spend their money wisely, according to their liberal agenda. Intent on strictly observing the code of business ethics, they start to make use of the "positive power of wealth" and embark on a life of philanthropy. They fund a number of chairs in peace studies to be established at, of all places, military academies. They also secure legislation by which companies are required to label their products according to the percentage of female executives employed by them. After they have launched several of their projects, their operations are increasingly considered un-American and officially put under surveillance. But whatever will happen - Marvin knows that he will be able to nourish his family, as he has been accorded tenure.
A Tenured Professor was republished as paperback by Houghton Mifflin in 2001 (ISBN 0-618-15455-8).
In academia, a fellow （学有专长的会士或同仁） is a member of a group of learned people who work together as peers in the pursuit of mutual knowledge or practice. Fellows may include visiting professors, postdoctoral researchers and doctoral researchers. It may also indicate an individual recipient of a graduate-level merit-based form of funding akin to a scholarship. - 博主回复(2016-12-7 02:52)：有人故意误导国人
- [21]张义国
- Interdisciplinary Research Center on Biology and Chemistry 这个翻译：Interdisciplinary Research Center focused on Biology and Chemistry
博主回复(2016-12-7 14:52)：正确：Interdisciplinary Research Center for Biology and Chemistry 这个翻译：Interdisciplinary Research Center focused on Biology and Chemistry。 “for” is better than "of", but not "on". if the latter is used In Chilish - 博主回复(2016-12-7 02:59)：既然明确了 化学及 生物， Crossdisciplinary 比较好。
- 博主回复(2016-12-7 02:51)：我也觉得 for 比较好。=德语常常用的fur。 on 是很怪的。
- [20]王毅翔
- tenured professor 翻译成 终生教授 及 Fellow 翻译成 院士 不知道是 谁 首先 发明的。
- 博主回复(2016-12-7 01:20)：tenured professor 翻译成 终生教授 及 Fellow 翻译成 院士 不知道是 谁 首先 发明的。
- [19]张义国
- Interdisciplinary Research Center on Biology and Chemistry 这个翻译：Interdisciplinary Research Center focused on Biology and Chemistry
- 博主回复(2016-12-6 22:52)：on vs. 'of' or 'for'
Interdisciplinary vs Crossdisciplinary
- [18]张义国
- 她英文还可以，但属于知识青年一代又是美国英文，与地道英国英语无法比之。
- 博主回复(2016-12-6 21:46)：这个翻译是否奇怪？
- 博主回复(2016-12-6 21:45)：Interdisciplinary Research Center on Biology and Chemistry
- [17]doctor5
- 博主回复(2016-12-7 08:03)：她的英文是不是不太好？
－－－－－－－－－－
大多数女人的英文都比男人的好。 - 博主回复(2016-12-6 21:33)：发音，写就不一定了。
你看看做个中心的英文翻译。
- [16]刘学武
- [2]pota 2016-12-7 06:10
终身教授 是否是正教授不重要。
哈佛医学院比中国最大的农贸市场-北京新发地农产品批发市场还大。后者才有3000个摊位，而前者10年前就有4024个各级教授了。美国助理教授就博导了，也就是说，一个哈佛医学院就有几千个博士点了。不过这还没有川大魏于全的动物房大，魏院士的动物房一年可毕业4万只科学小白鼠。川大院士只能在成都吃火锅，而哈佛博士能去瑞士喝咖啡。
这讽刺的好。 - 博主回复(2016-12-6 21:36)：哈佛医学院成为正教授非常 困难，而且 正教授的工资还是要靠基金的。
///// 袁博士是否 有意误导？
- [15]pota
- 从网上如何能看出实验室/教研室不是教授自己命名的呢？我没练过气功没这奇异功能。
//博主回复(2016-12-7 09:27)：但我猜想，该大学的许多实验室/教研室应该是教授自己命名的。
您老错了，肯定不是。 您老到网上看看就知道。
- [14]pota
- 你把我的有关鸦片和卖淫价格的评论删了，实在是可笑。研究那些社会现象是正儿八经非常有用的学问。
- [13]pota
- 我没直接在 Erasmus University Rotterdam 工作过，但我猜想，该大学的许多实验室/教研室应该是教授自己命名的。你在那里杀一年老鼠，对聘教授建新的实验室/教研室的事未必了解。
//博主回复(2016-12-7 08:17)：在欧陆，我直接在 Erasmus University Rotterdam 工作过一年。
http://www.erasmusmc.nl/radiologie/?lang=en
没有系主任名字什么事。 - 博主回复(2016-12-6 17:27)：废话了。
袁均英 博士 在 哈佛 做过 正教授吗。 有 还是 没有。请回答？ - 博主回复(2016-12-6 17:27)：但我猜想，该大学的许多实验室/教研室应该是教授自己命名的。
您老错了，肯定不是。 您老到网上看看就知道。 - 博主回复(2016-12-6 17:23)：我没有杀老鼠。
- [12]pota
- 兄弟在欧陆实验室刷试管的时候，你还在大陆背毛主席语录呢。
- 博主回复(2016-12-6 16:20)：
- [11]pota
- 欧陆有许多公有制大学实验室/教研室/研究所/的名字是教授自己命名的！这么说，够严谨了吧。
//博主回复(2016-12-7 08:13)：欧陆的大学基本是共有制，而其实验室/教研室/研究所/的名字是教授自己命名的。
------ 不是。 - 博主回复(2016-12-6 16:18)：反正我没有看到过，那说明 不是 许多 吧。
- [10]pota
- “本国文字第一” 这个我是完全同意你的。“笔画少”那是调侃讽刺。
- [9]pota
- 那说明你看问题就太表面化了。
欧陆的大学基本是共有制，而其实验室/教研室/研究所/的名字是教授自己命名的。没错，他们一般不会以自己的名字命名，否则就成了凤姐了，但他们的实验室名字下面就是教授的名字，这两者通常总是在一起的。
//博主回复(2016-12-7 08:05)：我在欧陆 及英国 没有看到过这样。
在 香港，更加不容许这样。 - 博主回复(2016-12-6 16:17)：在欧陆，我直接在 Erasmus University Rotterdam 工作过一年。
http://www.erasmusmc.nl/radiologie/?lang=en
没有系主任名字什么事。 - 博主回复(2016-12-6 16:14)：共有制 是对的 但是
实验室/教研室/研究所/的名字是教授自己命名的 -- 不对。 - 博主回复(2016-12-6 16:13)：欧陆的大学基本是共有制，而其实验室/教研室/研究所/的名字是教授自己命名的。
------ 不是。
- [8]张洛欣
- 袁在于Apoptosis 有关的 Signaling Pathway方面作过至少一个很重要的工作， 揭示了一个蛋白的功能。也许已经出现在教科书上。和王晓东作的方向很接近。
- 博主回复(2016-12-6 16:07)：听说 在哈佛医学院 做正教授，要为医学院 搞到 极大量的 钱。不光是学术 做得好。
- 博主回复(2016-12-6 16:06)：有没有做到正教授？
- [7]pota
- 2 为什么不用 本国文字？
笔画少。 Yan lab. 多简单！ - 博主回复(2016-12-6 16:08)：http://www.erasmusmc.nl/radiologie/?lang=en
https://strahlentherapie.charite.de
显示了，本国文字第一。
- [6]pota
- 那又不是房产证。//博主回复(2016-12-7 07:25)：如果是公共财产 我认为不能这么写。
- 博主回复(2016-12-6 16:05)：我在欧陆 及英国 没有看到过这样。
在 香港，更加不容许这样。
- [5]孟佳
- 另外yan lab应该没什么，美国都是这么用
- 博主回复(2016-12-6 15:25)：如果是公共财产 我认为不能这么写。
- [4]孟佳
- 应该这么说，她确实是终身正教授，不过医学院的tenure条款其实不怎么有内容
- 博主回复(2016-12-6 15:18)：我估计她是副教授。
- [3]pota
- 饶毅是美国西北大学的正教授吧，那又怎么样呢？根据《饶屠等价定理》（Rao-Butcher Equivalence Theorem)
http://baike.baidu.com/view/6444906.htm，一个美国正教授也就等价于两三个杀猪的屠夫。所以，区别终身教授和正教授，是比较圆周率小数点后面第三位。
- [2]pota
- 终身教授 是否是正教授不重要。
哈佛医学院比中国最大的农贸市场-北京新发地农产品批发市场还大。后者才有3000个摊位，而前者10年前就有4024个各级教授了。美国助理教授就博导了，也就是说，一个哈佛医学院就有几千个博士点了。不过这还没有川大魏于全的动物房大，魏院士的动物房一年可毕业4万只科学小白鼠。川大院士只能在成都吃火锅，而哈佛博士能去瑞士喝咖啡。 - 博主回复(2016-12-6 16:04)：是听说 哈佛医学院 规模 极大。
- [1]张义国
- 知道，也有了解，但是我认为她是袁世凯的孙女，华人生命科学做得最好之一。
其实美国公立大学tenured教授最多也只有9月工资，另外靠基金，而私立大学tenured只是一种荣誉不是全工资（大约3-6月，另外靠各种公私基金，但交很多bench租金及水电费用等），不同教授差异很大，由校长聘任为准。她在上海建了一个大实验室，与她学生PI有合作。 - 博主回复(2016-12-6 16:03)：她的英文是不是不太好？
