Telomerase reverse transcriptase synergizes with calorie restriction to increase longevity
Studies from Telomeres and Telomerase Group Update Current Data on Ribonucleoproteins
02-15-13
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Proteins have been published. According to news reporting from Madrid, Spain, by NewsRx journalists, research stated, "Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity." The news correspondents obtained a quote from the research from Telomeres and Telomerase Group, "This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts." According to the news reporters, the research concluded: "These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing 'health span' and extending mouse longevity." For more information on this research see: Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. Plos One, 2013;8(1):e53760. (Public Library of Science - www.plos.org; Plos One - www.plosone.org) Our news journalists report that additional information may be obtained by contacting E. Vera, Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, Madrid, Spain (see also Proteins). Keywords for this news article include: Spain, Madrid, Europe, Cancer, Genetics, Oncology, Proteomics, Telomerase, Carrier Proteins, Ribonucleoproteins, Phosphotransferases, Enzymes and Coenzymes, Reverse Transcriptase, DNA Nucleotidyltransferases, RNA Directed DNA Polymerase. Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .
2007 NewsRx.com. All Rights Reserved.Copyright 2013, Genomics & Genetics Weekly via NewsRx.com |
|
Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension. |
http://www.lef.org/news/LefDailyNews.htm?NewsID=18111&Section=Aging&utm_source=DailyHealthBulletin&utm_medium=email&utm_term=Aging&utm_content=Body+ContinueReading&utm_campaign=DHB_130219
