对,用药当然要考虑benefit vs risk.我不是说要盲目用药。但我知道对精神疾病的掩饰和对有关药物的忌讳,本身就是治疗的巨大障碍。
我过去的一篇文章供参考。谢谢。
https://blog.wenxuecity.com/myblog/80301/202307/7763.html
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回复 '唐宋韵' 的评论 : 用任何药,都会weigh benefit and risk, 我不否认抗抑郁药的效果,需要吃药的时候一定要吃。我那后来做了院长的同学已经出现强直木僵状态了,药物可以说救了他的命。这个boxed warning 仅是针对青少年,用药初需密切关注。我工作中经常开cymbalta, 因为这是目前临床试验认为这是治疗药物引起的周围神经病变最有效的方法,我们用药也是data driven,但是药物引起的周围神经病变真的太难治了。
Boxed warnings (formerly known as Black Box Warnings) are the highest safety-related warning that medications can have assigned by the Food and Drug Administration, 药厂哪愿意自己贴上这个标签。医生每次开药查询剂量时手都得抖一下。
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回复 '风铃在非洲' 的评论 : 你好!Serengeti National Park 是我特别想去的地方,五年前遇到一个在坦桑尼亚开厂的女子,这草就疯狂种上了。但胆小怕疟疾怕黄热病怕登革。
回复 '唐宋韵' 的评论 :拿Zoloft 举例,
ALERT: US Boxed Warning
Suicidality and antidepressant drugs:
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.
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回复 '唐宋韵' 的评论 : 谢谢clarify. 如果有严重的抑郁症,确实要用药。N年前曾目击电休克治疗,当时就想病人得多绝望才同意这种治疗。我不做精神病科,在美也只是许多年前住院医时在那个科轮转了二周。据up to date: The advantage of antidepressants over placebo is typically 2 to 4 points on a standard rating scale, such as the 17-item Hamilton Rating Scale for Depression. The small advantage of antidepressants over placebo in depressed patients is due in part to the nonspecific clinical effects of placebo treatment; receiving placebos in clinical trials is not equivalent to receiving no treatment. the FDA found that among the 74 registered trials, only 51 percent were positive. A pooled analysis of four randomized trials found that the mean time to improvement (reduction of baseline symptoms ≥20 percent) in patients treated with antidepressants (n>2000) was approximately 13 days