XL-880 effective

News of the day:

In pts [patients] with PRC, XL-880 demonstrated antitumor activity

NameTargetCompanyPhase
AZD-2171Vegf c-Kit Pdgfr-βAstraZenecaph2
AZD-2171Vegf c-Kit Pdgfr-βAstraZenecaph2
PD-325901MekPfizerph2
XL-647ErbB1,2 Vegfr-2Exelixisph2
XL-880c-Met VegfExelixisph2
ARQ-197c-MetArquleph1
BAY-579352Vegfr-2,3 c-Kit Pdgfr-βBayerph1
BAY-734506c-Kit Ret Pdgfr RafBayerph1
BIBW-2992ErbB (irrev)BIph1
PD-325901MekPfizerph1
PF-299804ErbB (irrev)Pfizerph1
TicribineAktVioQuestph1
XL-647ErbB 1,2 Vegfr-2Exelixisph1
XL-820Vegfr c-Kit PdgfrExelixisph1
XL-880c-Met VegfExelixisph1
ARRY-543ErbB1, 2Arrayph1
AT-13148Akt Rock PKAAstex 
AV-951VegfAveoph1
BAY-734506c-Kit Ret Pdgfr RafBayer 
BMS-698769c-MetBMS 
CEP-11981Tie2 VegfrCephalon 
CUDC-101HDAC / ErbBCuris 
NVP-BEZ235Pi3kNovartis 
OSI-906IGF-1ROsi 
RDEA-119MekArdea 
SGX-523c-MetSGX 
SR-13654SrcSRI 
XL-765Pi3k, mTORExelixis 
XL-820c-KitExelixis 
XL-844Chk1, 2Exelixis 
ZD-6474Vegfr-2 EGFR  
ZM 447439Aurora  
CRT-59359PKDCRT 
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